In recent years advances in and fiber tractography have enabled

In recent years  FIFA 17 coins packs advances in and fiber tractography have enabled their application as clinical tools in the assessment of CNS diseases. Using DTI, several key elements will emerge in the future study CNS diseases. First, since highly ordered white matter fiber tracts have components of both axon and myelin (and DTI can evaluate properties that vary with the space, shape, and direction of the compartment that is accessible to the water molecule), DTI has the potential to decode these properties in order to differentiate the origin of tissue injury, to see whether only myelin or both myelin and axonal injury occurs.

This has been  Fifa Coins shown in some experimental work by decoding axial and radial diffusivity of the optic nerve in animal studies. The application in human brain will have clinical significance in terms of characterizing the severity of tissue injury and differentiating axonal injury, demyelination, and remyelination during lesion evolution. In part, the separation of DTI information into individual directional eigenvalues may impart more specificity in characterizing the underlying pathophysiology. Second, the emerging technique of fiber tactography from DTI data has a major impact on visualizing and quantifying axonal fibers in vivo.

Future research using fiber tracking technology can provide direct evidence not only for clinical manifestations caused by pathology at the primary site where axonal injury occurs, but also for secondary degenerative processes caused by axonal pathway transection at a distant site. High angular resolution diffusion imaging (HARDI) techniques will allow for the study of complex white matter architecture, where multiple crossing fibers may intersect in different directions within a single voxel. 10 Third, validation of DTI metrics in normal tissue and histopathological validation of DTI metrics for various pathologies is a challenge but will help resolve many questions regarding the specific characterization of tissue damage at different stages of different disease processes

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